Kentucky Medication Aide (KMA) State Practice Exam

What is the main action of oral hypoglycemics like Glyburide?

1. To increase glucose production in the liver

2. To lower blood glucose by stimulating insulin release

3. To decrease insulin sensitivity

4. To inhibit glucagon secretion

The correct answer is: To lower blood glucose by stimulating insulin release

The main action of oral hypoglycemics like Glyburide is to lower blood glucose levels by stimulating insulin release from the pancreas. Glyburide belongs to a class of medications called sulfonylureas, which work by increasing the secretion of insulin in response to elevated blood glucose levels. This is particularly important for individuals with type 2 diabetes who have insufficient insulin production or insulin resistance. When blood sugar levels rise after meals, the pancreas releases insulin, which allows glucose to enter the cells and be used for energy or stored for later use. By stimulating this process, Glyburide effectively aids in controlling blood sugar levels, helping to prevent the complications associated with diabetes. This mechanism is central to the management of type 2 diabetes and emphasizes the role of insulin in glucose regulation.